Partey has been one of Arsenal’s standout players this season and is one of the main reasons why the Gunners sit at the top of the table.
The Ghana international has played 18 Premier League games this season for Mikel Arteta’s side, contributing two goals so far.
According to a report by The Athletic, the midfielder’s injury is not serious but the club decided to be careful not to risk Manchester City.
Meanwhile, Arsenal are now just three points clear of Guardiola’s side ahead of Wednesday’s crucial meeting between the two sides.
If Manchester City win the game, they will pip the Gunners at the top of the table on goal difference, although Arteta’s side have a game in hand.
Speaking ahead of the match, the Arsenal manager said his side were looking to get back to winning ways after failing to win each of their last two league games.
“Are they the same? [City] have done in the last six years, they deserve it,” Arteta told the media.
“The way he plays, the way he competes, the way he goes through difficulties. For us, it’s a challenge to reach that level.
Meanwhile, Arsenal can move six points clear at the top of the table if they win against Manchester City.