The Black Stars topped Group E after Thursday’s win over Palencas Negras.
The 33-year-old later complained of pain early on Saturday and tests confirmed he had injured his knee on Thursday.
According to GFA director of communications, Henry Asante Twum, “He came to complain this morning about a knee injury. The team doctor carried out preliminary tests on him and concluded that he should return to England for further scans.
The Nottingham Forest man, will not travel with the squad to Luanda after permission was given by the team doctor.
Mohammed Salisu, Denis Odoi, and Alexander Djiku have also been ruled out of the Angola game on Monday due to injuries.